Epileptogenesis

Matrix metalloproteinases and epileptogenesis

Matrix metalloproteinases are vital drivers of synaptic remodeling in health and disease. It is suggested that at early stages of epileptogenesis, inhibition of matrix metalloproteinases may help ameliorate cell death, aberrant network rewiring, and neuroinflammation and prevent development of epilepsy.

CNS Inflammation and Epileptogenesis

An association between acute CNS infections and seizures is reported in the literature. The etiology of these seizures is, in some cases, precipitated by epileptogenic pathogenesis of the infectious agent in the brain parenchyma. A different etiology of seizures as a consequence of infections, independent of the infectious agent, relates to the inflammatory reaction. Thirdly, the febrile respon...

Neuronal mechanisms of epileptogenesis

The primary purpose of this topic is to collect scientific contributions providing novel insights in the cellular and molecular mechanisms of epileptogenesis as potential targets for innovative therapeutic approaches aimed at preventing the chronic epileptic disorder. Prevention of chronic epileptic disorder with an appropriate intervention might represent the most ambitious goal in the clinica...

From: MECHANISMS OF EPILEPTOGENESIS

Calcific neurocysticercosis and epileptogenesis.

Neurocysticercosis is responsible for increased rates of seizures and epilepsy in endemic regions. The most common form of the disease, chronic calcific neurocysticercosis, is the end result of the host's inflammatory response to the larval cysticercus of Taenia solium. There is increasing evidence indicating that calcific cysticercosis is not clinically inactive but a cause of seizures or foca...